Everyone Should Take: NAC!
Last time I wrote a whole article about n-acetylcysteine, it was 2010, and there was already a impressive body of research on NAC. But now – wow! As of today, PubMed (the National Institutes of Health’s medical database) lists a whopping 1,163 clinical trials on or involving this powerful nutrient. I’m not going to claim NAC works in every single one of these trials. In fact, even surveying the most recent three, we can safely say it works in two (liver impairment following surgery, fertility enhancement in PCOS), and fails in the third (symptoms of Sjogren’s syndrome). But, it sure works in a lot of them. And it’s a testament to how much good it can do that it’s being researched in so many ways at all! Here are some of the things NAC can do: |
- strengthen the immune system, significantly and consistently
- improve liver health, and protect the liver from toxic damage
- improve lung health, and protect the lungs from toxic damage
- reduce compulsive and addictive behavior in adults and adolescents
- protect the brain, heart, and kidneys from functional and structural deterioration due to strain and aging
- improve outcomes in high-risk pregnancies
- reduce and health from inflammatory bowel disease
- improve surgical outcomes
- decongest (thin mucous)
And having enumerated all that, what impresses me most isn’t how helpful NAC can be for any specific thing, but how helpful it is for… everything. This isn’t just a medicine for when you’re sick in a specific way. This is a tonic, a tune-up, and an optimizer. How can one nutrient do all this? Well, NAC is a precursor to the substance glutathione, the body’s #1 protective compound, produced in every cell. Glutathione detoxifies wastes, pollutants, and radiation; repairs cell damage; and rebalances neurotransmitters. It reduces oxidative stress and inflammation. When glutathione is depleted, cell function gets “gunked up.” Immune cells become less active. Muscles feel weak, and take longer to recover. Brain cells become less active. All cells become susceptible breakdown caused by inflammation. All of which begs the question: why not just take glutathione? Actually, you can. But oral glutathione absorbs poorly. Meanwhile, NAC absorbs great, and helps the body make glutathione exactly when and where it’s needed. You could try liposomal glutathione. It’s more bioavailable, and we sell it. But it’s pricy, and may or may not do any better than NAC. NAC and Immunity: the most impressive study I’ve ever seen on flu prevention was an Italian trial with NAC. 262 elderly men took either 2 NAC pills a day, or placebo, for six months. Afterwards, blood tests confirmed that both groups had been exposed to the flu at equal rates. But when it came to the symptoms, 79% of the people in the placebo group exposed to the flu reported flu symptoms, compared to only 25% in the NAC group. There’s also a good study where NAC taken at the onset of a cold cuts symptoms and sick days by half, and quite a bit of research where it reduces respiratory symptoms of viral infections. Turns out, immune cells “get tired,” correlating directly with depleting glutathione. Restoring reservoirs of glutathione returns them to activity. PLUS, glutathione mops up some of the damage (inflammatory symptoms) caused by an immune response. So it’s a double-win. NAC and Mental/Emotional Health: glutathione’s role in the brain is complicated. It is itself a sort of neurotransmitter. Plus it helps modulate the level and function of other neurotransmitters. Plus it protects brain cells from damage, deterioration, and aging. Low glutathione is linked to brain injury, premature aging, schizophrenia, and depression. AND YET – glutathione and/or NAC doesn’t effect people who are “normal” (I hate that judgy word, but bear with me). It’s not going to change your mood if everything is already fine. NAC rarely helps in garden-variety depression or anxiety – at least, not much. Where we do see benefit is around compulsive behavior (there’s been some research around teen girls), and possibly bipolar disorder. In both cases, we need to be patient: sometimes months of continuous supplementation before we see benefit. NAC may also help people detox and recover from addictive drugs (although this research so far has just involved animals). NAC and Neurologic Health: it gets pretty technical, and none of it is really conclusive, but it looks like NAC can protect the brain from inflammation and aging. It’s pretty hard to do the real research we need here, since for something as nebulous as “aging” you’d need to track thousands of people for dozens of years – and then probably dissect the brain at the end of it. But the preliminary research is pretty compelling – enough that it makes me want to take it. NAC and Pregnancy: I don’t really want to get into it too much here, but there are a number of very compelling small clinical trials where NAC improves outcomes in a variety of kinds of high-risk pregnancy. Recurrent miscarriage, stillbirth, etc. Like I said, I don’t really want to get into it here. Mostly, I’m trying to make the point that NAC has been researched repeatedly in pregnancy, and it appears to be quite safe. NAC and the Lungs: I said NAC is all about increasing glutathione. Actually, there’s one other thing NAC does, and that’s thin mucous, a.k.a. “decongest.” And having said that, the lungs love and rely on glutathione too. Glutathione is central to the lungs’ ability to protect their vulnerable tissues, tamp down inflammation, and maintain healthy function through all the beating they take on a daily basis. So we see a number of studies where long-term glutathione flare-ups in chronic lung conditions like COPD and chronic bronchitis. (Unfortunately, there appears to be minimal benefit with asthma…). On top of that, there’s good evidence that NAC can greatly speed recovery from an infection that involves the lungs. There was even a rat study where NAC was highly protective when they were exposed to chemical warfare agents (mustard gas). NAC and the Heart, Gut, and Kidneys: NAC isn’t an anti-inflammatory in the classical sense of the word, where it directly reduces inflammation. However, it can mop up the damage left behind by inflammation before it damages tissues. Most chronic degenerative diseases that are driven by inflammation can benefit from NAC supplementation. Again, there’s some interesting evidence here…. How much to Take? This is an easy one. The dose used in study after study after study is 600 mg twice a day. That’s how much I take. Interactions? The minerals selenium, molybdenum, and zinc; and vitamin C, can help convert NAC to glutathione. |